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KMID : 0861020070220020181
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Korea Journal of Herbology
2007 Volume.22 No. 2 p.181 ~ p.188
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Study on the Attributive Channel Theory by the Pharmacodynamic Research of I-131 labelled Curcumin
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Yun Hong-Il
Ham In-Hye
Cho Jung-Hyuck
Yu Kook-Hyun
Park Jeong-Hoon
Choi Ho-Young
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Abstract
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Objectives : This study was to verify the Attributive Channel theory of herbal medicine.
Methods : [13lI]iodocurcumin was synthesized, separated, and refined from curcumin, the major component of Curcuma species, followed by observing the biodistribution in an organism. Especially, from the fact that curcumin has shown to possess potent anti-carcinogenic properties, the biodistribution in the carcinogenesis organism was analyzed.
Result : Iodocurcumin 23mg was obtained through column chromatography after a reaction with 50mg of Curcumin and ICl. The nominal yield of [13lI]iodocurcumin synthesis was 35% when checked with radioactive layer of chromatography. [13lI]iodocurcumin was most largely distributed in the stomach of a BALB/c mouse and a C57BL/6 mouse transplanted with Lewis lung carcinoma cell.
Conclusion : The fact that [13lI]iodocurcumin was most largely distributed in the stomach was related with the Attributive Channel theory. And there was no significant finding related to tumor cells.
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KEYWORD
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Attributive Channel, Curcuma, I-131 labelled Curcumin, [131I]iodocurcumin, curcumin, iodocurcumin, biodistribution
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